Current Issue : July - September Volume : 2018 Issue Number : 3 Articles : 5 Articles
Objective. We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH\nlevels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH. Methods. Patients who\nunderwent clinical FDG-PET/CTwere reviewed andwe categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW)\ngroup; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT\ngroup. A total of sixty-two FDG-PET/CT imaging studies in fifty-nine patients were performed. To compare each group, gender;\nage; body weight; serum TSH, FT3, and FT4 levels; and outside temperature were evaluated. Results. No significant visualization\nof BAT was noted in any of the images in the THW, rhTSH, hypothyroidism, and hyperthyroidism groups. All patients in the BAT\ngroup were in a euthyroid state. When the BAT-negative and BAT-positive patient groups were compared, it was noted that the\nminimum andmaximum temperature on the day of the PET study and maximum temperature of the one day before the PET study\nwere significantly lower in BAT-positive group than in all those of other groups. Conclusions. Elevated TSH condition before RIT,\nhyperthyroidism, or hypothyroidism did not significantly impact BAT visualization of clinical FDG-PET/CT images....
Magnetic resonance imaging (MRI) combined with contrast agents is believed to be useful for stemcell tracking in vivo, and the aim\nof this research was to investigate the biosafety and neural induction of SD rat-originated adipose derived stem cells (ADSCs) using\ncationic superparamagnetic iron oxide (SPIO) nanoparticlewhich was synthesized by the improved polyol method, in order to allow\nvisualization using in vitro MRI. The scan protocols were performed with T2-mapping sequence; meanwhile, the ultrastructure\nof labeled cells was observed by transmission electron microscopy (TEM) while the iron content was measured by inductively\ncoupled plasma-atomic emission spectrometry (ICP-AES).After neural induction, nestin andNSE (neural markers) were obviously\nexpressed. In vitroMRI showed that the cationic PEG/PEI-modified SPIOnanoparticles could achieve great relaxation performance\nand favourable longevity. And the ICP-AES quantified the lowest iron content that could be detected by MRI as 1.56âË?¼1.8 pg/cell.\nThis study showed that the cationic SPIO could be directly used to label ADSCs, which could then inductively differentiate into\nnerve and be imaged by in vitro MRI, which would exhibit important guiding significance for the further in vivo MRI towards\nanimal models with neurodegenerative disorders...
Molecular imaging probes such as PET-tracers have the potential to improve the accuracy of tumor characterization by directly\nvisualizing the biochemical situation. Thus, molecular changes can be detected early before morphological manifestation. The\nA3 adenosine receptor (A3AR) is described to be highly expressed in colon cancer cell lines and human colorectal cancer\n(CRC), suggesting this receptor as a tumor marker. The aim of this preclinical study was the evaluation of [18F]FE@SUPPY\nas a PET-tracer for CRC using in vitro imaging and in vivo PET imaging. First, affinity and selectivity of FE@SUPPY and its\nmetabolites were determined, proving the favorable binding profile of FE@SUPPY. The human adenocarcinoma cell line HT-29\nwas characterized regarding its hA3AR expression and was subsequently chosen as tumor graft. Promising results regarding the\npotential of [18F]FE@SUPPY as a PET-tracer for CRC imaging were obtained by autoradiography as �2.3-fold higher accumulation\nof [18F]FE@SUPPY was found in CRC tissue compared to adjacent healthy colon tissue fromthe same patient. Nevertheless, first in\nvivo studies usingHT-29 xenografts showed insufficient tumor uptake due to (1) poor conservation of target expression in xenografts\nand (2) unfavorable pharmacokinetics of [18F]FE@SUPPY in mice.We therefore conclude that HT-29 xenografts are not adequate\nto visualize hA3ARs using [18F]FE@SUPPY....
During the last decade, the utilization of 68Ga for the development of imaging agents has increased considerably with the leading\nposition in the oncology. The imaging of infection and inflammation is lagging despite strong unmet medical needs. This review\npresents the potential routes for the development of 68Ga-based agents for the imaging and quantification of infection and\ninflammation in various diseases and connection of the diagnosis to the treatment for the individualized patient management....
Objectives. 18F-FDG PET scan is one of the most frequently used neural imaging scans. However, the influence of age has proven\nto be the greatest interfering factor for many clinical dementia diagnoses when analyzing 18F-FDG PET images, since radiologists\nencounter difficulties when deciding whether the abnormalities in specific regions correlate with normal aging, disease, or both. In\nthe present paper, the authors aimed to define specific brain regions and determine an age-correction mathematicalmodel. Methods.\nA data-driven approach was used based on 255 healthy subjects. Results. The inferior frontal gyrus, the left medial part and the left\nmedial orbital part of superior frontal gyrus, the right insula, the left anterior cingulate, the left median cingulate, and paracingulate\ngyri, and bilateral superior temporal gyriwere found to have a strong negative correlation with age. For evaluation, an age-correction\nmodel was applied to 262 healthy subjects and 50 AD subjects selected from the ADNI database, and partial correlations between\nSUVR mean and three clinical results were carried out before and after age correction. Conclusion. All correlation coefficients were\nsignificantly improved after the age correction. The proposed model was effective in the age correction of both healthy and AD\nsubjects....
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